Across TCGA pan-cancer cohorts, H2BU1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated H2BU1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher H2BU1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2BU1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

KIRP, COAD, and BRCA are the cancer types where H2BU1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.772	0.937	<.001	83	view →
COAD	OS	Median	II,III,IV	0.800	0.898	.002	70	view →
BRCA	DFS	Tertile	II,III,IV	0.917	0.857	.005	41	view →
LGG	OS	Median	All	0.868	0.744	<.001	37	view →
UVM	DFS	Median	II,III,IV	0.343	0.732	.005	34	view →
LIHC	OS	Quartile	II,III,IV	0.488	0.825	.003	24	view →
MESO	DFS	Tertile	IV	0.193	0.544	.007	18	view →
PAAD	DFS	Median	II,III,IV	0.250	0.371	.008	17	view →
SKCM	OS	Median	All	0.826	0.913	.008	16	view →
UCEC	DFS	Quartile	All	0.868	0.934	.004	16	view →
THCA	DFS	Tertile	III,IV	0.853	0.596	.012	15	view →
HNSC	DFS	Median	All	0.264	0.414	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: H2BU1 tumor-vs-normal RNA expression · all H2BU1 data types