H2BC9

Across TCGA patient cohorts, H2BC9 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible H2BC9-associated genes across cancer lineages are NME1P1, RNU6-506P, and RNU6-642P. Each is linked with H2BC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC9-to-partner and partner-to-H2BC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NME1P1 grouped by H2BC9-low versus H2BC9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC9→partner) and Y-score (partner→H2BC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NME1P1 →	+0.092	+5.669	.002	.003	3	2
OV	RNU6-506P →	+0.303	+5.137	.001	.007	3	2
BRCA	RNU6-642P →	+0.478	+5.096	<.001	.008	3	2
BRCA	VN1R32P →	+0.101	+6.711	<.001	<.001	3	2
BRCA	RN7SL41P →	+0.261	+5.409	<.001	.005	3	2
BRCA	RN7SL810P →	+0.222	+5.540	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

NME1P1 by H2BC9 expression — CESC

Explore this box plot interactively →