H2BC9

Across TCGA pan-cancer cohorts, H2BC9 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of H2BC9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2BC9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BC9 is over-expressed in tumor.

HNSC, BLCA, and KIRC are the cancer types where H2BC9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BC9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.952	<.001	11	view →
BLCA	All	III,IV	+2.879	<.001	10	view →
KIRC	Male	II,III,IV	+0.534	<.001	9	view →
LUSC	Female	II,III,IV	+3.208	<.001	8	view →
BRCA	All	III,IV	+2.469	<.001	8	view →
LUAD	Male	All	+1.955	<.001	8	view →
LIHC	All	II,III,IV	+0.613	<.001	8	view →
STAD	All	II,III,IV	+1.672	<.001	7	view →
KIRP	Male	All	+0.508	<.001	7	view →
UCEC	All	III,IV	+3.373	<.001	6	view →
COAD	Female	All	+0.762	.001	4	view →
ESCA	Female	All	+2.900	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

H2BC9–HNSC

Open the HNSC breakdown →