H2BC7

Across TCGA patient cohorts, H2BC7 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC7-associated genes across cancer lineages are H3P18, RNU6-369P, and RNA5SP22. Each is linked with H2BC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC7-to-partner and partner-to-H2BC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P18 grouped by H2BC7-low versus H2BC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC7→partner) and Y-score (partner→H2BC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3P18 →	+0.826	+4.296	<.001	.003	3	2
THCA	RNU6-369P →	+0.242	+7.962	<.001	.007	3	1
THCA	RNA5SP22 →	+0.304	+7.962	<.001	.007	3	1
THCA	RPS29P13 →	+0.284	+7.962	<.001	.007	3	1
THCA	TTTY18 →	+0.164	+7.962	<.001	.007	3	1
THCA	IGLVVI-22-1 →	+0.528	+7.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

H3P18 by H2BC7 expression — UCEC

Explore this box plot interactively →