H2BC7

Across TCGA pan-cancer cohorts, H2BC7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated H2BC7 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher H2BC7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2BC7 expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

KIRP, ACC, and STAD are the cancer types where H2BC7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.504	0.932	<.001	100	view →
ACC	OS	Median	All	0.372	0.807	<.001	87	view →
STAD	OS	Median	III,IV	0.596	0.282	.001	60	view →
SCLC	OS	Median	II,III,IV	0.732	0.382	<.001	53	view →
KIRC	DFS	Median	All	0.546	0.710	<.001	48	view →
THCA	OS	Tertile	All	0.955	0.995	.005	39	view →
CESC	OS	Median	II,III,IV	0.852	0.642	.003	38	view →
DLBC	DFS	Median	All	0.966	0.599	.002	28	view →
LUAD	OS	Median	II,III,IV	0.551	0.787	.001	25	view →
ESCA	DFS	Quartile	All	0.389	0.638	.005	23	view →
READ	OS	Tertile	III,IV	0.288	0.840	.016	12	view →
LGG	OS	Tertile	All	0.872	0.965	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

H2BC7–KIRP (OS)

Open the KIRP breakdown →