H2BC11

Across TCGA patient cohorts, H2BC11 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. STAD shows the largest number of these associations.

The most reproducible H2BC11-associated genes across cancer lineages are TRIM64EP, RNU6-441P, and MIR133B. Each is linked with H2BC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC11-to-partner and partner-to-H2BC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64EP grouped by H2BC11-low versus H2BC11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC11→partner) and Y-score (partner→H2BC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRIM64EP →	+0.141	+6.624	<.001	.001	3	2
STAD	RNU6-441P →	+0.401	+5.366	.008	.005	3	2
UCEC	MIR133B →	+0.356	+8.066	<.001	.007	3	2
BLCA	OR4F13P →	+0.035	+6.018	<.001	.002	3	1
BLCA	ZNF25-DT →	+0.146	+5.329	<.001	.006	3	1
BLCA	LINC01846 →	+0.369	+5.106	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TRIM64EP by H2BC11 expression — SKCM

Explore this box plot interactively →