Across TCGA patient cohorts, H2AP mutation is significantly associated with the RNA expression of many other genes, with 739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AP-associated genes across cancer lineages are MIR7845, SNORD66, and PTPRJ. Each is linked with H2AP in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AP-to-partner and partner-to-H2AP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AP→partner) and Y-score (partner→H2AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR7845 →	+0.684	+4.345	<.001	.007	3	2
LUAD	SNORD66 →	+0.691	+4.293	.001	.008	3	2
UCEC	PTPRJ →	+0.632	+3.346	.009	.005	3	1
UCEC	PRSS53 →	+0.281	+2.190	.003	.009	3	1
UCEC	TEX30 →	+0.691	+3.593	.002	.001	3	1
UCEC	HAUS1 →	+0.597	+3.480	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

Exploration

H2AP survival (RNA) · tumor vs normal (RNA) · all H2AP data types