Across TCGA pan-cancer cohorts, H2AP RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of H2AP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AP is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where H2AP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.122	.023	7	view →
BRCA	All	All	+0.190	<.001	6	view →
KIRC	All	II,III,IV	−0.024	.008	6	view →
LUSC	All	All	+0.276	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: H2AP RNA expression & survival · all H2AP data types