Across TCGA pan-cancer cohorts, H2AP RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated H2AP data layer compared with 4 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher H2AP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AP expression acts as an unfavorable survival marker, although some lineages such as ACC and BLCA show a favorable association.
KIRC, LUSC, and LUAD are the cancer types where H2AP RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.