Across TCGA patient cohorts, H2AP mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AP-associated genes across cancer lineages are FOXO3a_pS318_S321, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with H2AP in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AP-to-partner and partner-to-H2AP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AP→partner) and Y-score (partner→H2AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.167	-3.575	.004	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.498	+2.584	.035	.011	3	1
UCEC	INPP4B →	-0.344	-2.571	.022	.011	3	1
UCEC	p27_pT198 →	+0.158	+3.000	.001	.036	3	1
UCEC	PDCD4 →	-0.434	-2.584	.048	.011	3	1
UCEC	Raptor →	-0.161	-2.999	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

H2AP survival (RNA) · tumor vs normal (RNA) · all H2AP data types