H2AJ

Across TCGA patient cohorts, H2AJ mutation is significantly associated with the RNA expression of many other genes, with 2,151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AJ-associated genes across cancer lineages are HOXC5, TRAJ12, and RNU6-588P. Each is linked with H2AJ in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AJ-to-partner and partner-to-H2AJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXC5 grouped by H2AJ-low versus H2AJ-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AJ→partner) and Y-score (partner→H2AJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HOXC5 →	+0.198	+3.627	.001	.008	3	2
CESC	TRAJ12 →	+0.766	+3.930	<.001	<.001	3	2
CESC	RNU6-588P →	+0.287	+3.239	.001	.005	3	2
UCEC	LINC02132 →	+0.167	+2.470	.002	.001	3	2
UCEC	MIA-RAB4B →	+0.062	+2.033	.003	.003	3	2
UCEC	RNU6-705P →	+0.599	+1.885	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,151 associations by consensus.

HOXC5 by H2AJ expression — COAD

Explore this box plot interactively →