H2AJ

Across TCGA pan-cancer cohorts, H2AJ RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated H2AJ data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H2AJ RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AJ expression acts as an unfavorable survival marker, although some lineages such as BLCA and OV show a favorable association.

HNSC, KIRC, and BLCA are the cancer types where H2AJ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.312	0.499	<.001	66	view →
KIRC	DFS	Quartile	III,IV	0.567	0.852	.001	60	view →
BLCA	DFS	Quartile	All	0.746	0.463	.004	41	view →
LGG	OS	Median	All	0.847	0.941	<.001	40	view →
GBM	OS	Median	All	0.334	0.487	<.001	36	view →
OV	DFS	Tertile	II,III,IV	0.591	0.501	.012	36	view →
READ	DFS	Tertile	III,IV	0.833	0.296	<.001	36	view →
LAML	DFS	Quartile	All	0.284	0.520	.018	30	view →
UVM	OS	Median	All	0.490	0.832	.005	27	view →
ACC	DFS	Tertile	IV	0.668	0.096	.001	26	view →
SKCM	OS	Tertile	All	0.207	0.379	<.001	24	view →
LUSC	OS	Quartile	II,III,IV	0.827	0.642	.014	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

H2AJ–HNSC (OS)

Open the HNSC breakdown →