H2AJ

Across TCGA pan-cancer cohorts, H2AJ RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H2AJ’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where H2AJ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AJ is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

KIRP, LIHC, and KIRC are the cancer types where H2AJ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AJ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.977	<.001	11	view →
LIHC	Male	II,III,IV	+1.288	<.001	9	view →
KIRC	All	All	+0.317	.001	8	view →
UCEC	All	All	−1.122	<.001	6	view →
LUAD	Female	All	−0.534	<.001	6	view →
THCA	All	All	+0.370	<.001	6	view →
HNSC	All	II,III,IV	−0.429	.006	5	view →
BRCA	All	All	+0.304	.015	4	view →
CHOL	All	All	+1.783	<.001	3	view →
PRAD	All	All	+0.879	<.001	2	view →
BLCA	All	IV	+0.747	.004	2	view →
KICH	All	IV	−0.705	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

H2AJ–KIRP

Open the KIRP breakdown →