H2AJ

Across TCGA cell cohorts, H2AJ mutation is significantly associated with the mutation status of many other genes, with 1,502 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H2AJ-associated genes across cancer lineages are ALPP, NBPF10, and VTN. Each is linked with H2AJ in more than 2 cancer types. Because this analysis shows association rather than direction, both H2AJ-to-partner and partner-to-H2AJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALPP grouped by H2AJ-low versus H2AJ-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AJ→partner) and Y-score (partner→H2AJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ALPP →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	NBPF10 →	+4.502	+5.066	.007	.007	1	2
LUNG_SCLC	VTN →	+4.502	+5.066	.007	.007	1	2
LARGE_INTESTINE	USP51 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	DND1 →	+3.744	+4.044	.003	.003	1	2
LUNG_SCLC	ZNF496 →	+4.502	+5.066	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,502 associations by consensus.

ALPP by H2AJ expression — LUNG_SCLC

Explore this box plot interactively →