H2AC12

Across TCGA cell cohorts, H2AC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,209 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H2AC12-associated GO terms across cancer lineages are DNA replication checkpoint signaling, Interstrand cross-link repair, and Mitochondrial DNA repair. Each is linked with H2AC12 in more than 9 cancer types. Because this analysis shows association rather than direction, both H2AC12-to-partner and partner-to-H2AC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by H2AC12-low versus H2AC12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC12→partner) and Y-score (partner→H2AC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	+0.197	+0.632	<.001	.001	3	10
PANCREAS	Interstrand cross-link repair →	+0.082	+0.478	<.001	.001	3	9
BONE	Mitochondrial DNA repair →	+0.114	+0.492	.006	.004	3	9
PANCREAS	DNA replication initiation →	+0.132	+0.484	.001	<.001	3	9
PANCREAS	Positive regulation of mitotic sister chromatid separation →	+0.144	+0.419	<.001	.003	3	8
OESOPHAGUS	DNA strand elongation involved in DNA replication →	+0.143	+0.668	.004	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,209 associations by consensus.

DNA replication checkpoint signaling by H2AC12 expression — BONE

Explore this box plot interactively →