H2AC12

Across TCGA pan-cancer cohorts, H2AC12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of H2AC12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AC12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AC12 is over-expressed in tumor.

HNSC, STAD, and UCEC are the cancer types where H2AC12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AC12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.640	<.001	11	view →
STAD	Female	All	+1.248	<.001	8	view →
UCEC	All	III,IV	+0.605	<.001	6	view →
COAD	All	II,III,IV	+0.385	<.001	6	view →
BLCA	Female	All	+0.506	.003	5	view →
LUSC	Male	All	+0.449	<.001	5	view →
LIHC	Male	All	+0.145	<.001	5	view →
READ	All	III,IV	+0.585	<.001	4	view →
LUAD	All	All	+0.554	.011	4	view →
BRCA	All	All	+0.356	<.001	4	view →
CHOL	All	II,III,IV	+0.245	<.001	4	view →
PRAD	All	All	+0.159	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

H2AC12–HNSC

Open the HNSC breakdown →