H2AC12

Across TCGA pan-cancer cohorts, H2AC12 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated H2AC12 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher H2AC12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2AC12 expression acts as an unfavorable survival marker, although some lineages such as DLBC and BLCA show a favorable association.

KICH, ACC, and LGG are the cancer types where H2AC12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.597	0.952	<.001	91	view →
ACC	OS	Tertile	All	0.641	0.959	<.001	59	view →
LGG	DFS	Median	All	0.274	0.503	<.001	48	view →
DLBC	DFS	Median	All	0.980	0.652	.002	47	view →
THCA	OS	Median	III,IV	0.722	0.928	.002	43	view →
HNSC	OS	Median	All	0.606	0.712	.003	42	view →
BLCA	OS	Tertile	IV	0.371	0.118	.004	29	view →
MESO	OS	Tertile	IV	0.402	0.815	.002	25	view →
ESCA	DFS	Median	All	0.402	0.589	.005	22	view →
STAD	OS	Median	III,IV	0.700	0.561	.013	17	view →
THYM	OS	Tertile	All	0.954	0.543	.003	14	view →
OV	OS	Tertile	III,IV	0.363	0.279	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

H2AC12–KICH (DFS)

Open the KICH breakdown →