H1-8

Across TCGA cell cohorts, H1-8 RNA expression is significantly associated with the mutation status of many other genes, with 144 significant associations in total. CNS shows the largest number of these associations.

The most reproducible H1-8-associated genes across cancer lineages are KRT20, ZNF335, and CCNB3. Each is linked with H1-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-8-to-partner and partner-to-H1-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT20 grouped by H1-8-low versus H1-8-high in BREAST.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-8→partner) and Y-score (partner→H1-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRT20 →	+5.169	+0.038	.005	<.001	3	2
CNS	ZNF335 →	+4.035	+0.012	.006	<.001	3	2
CNS	CCNB3 →	+5.357	+0.022	.001	<.001	3	2
CNS	ZNF775 →	+5.357	+0.022	.001	<.001	3	2
LUNG_SCLC	KCNV1 →	+3.169	+0.071	.001	.002	3	2
OVARY	SEC14L5 →	+5.196	+0.059	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

KRT20 by H1-8 expression — BREAST

Explore this box plot interactively →