H1-8

Across TCGA pan-cancer cohorts, H1-8 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated H1-8 data layer compared with 4 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher H1-8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H1-8 expression acts as an unfavorable survival marker, although some lineages such as MESO and CESC show a favorable association.

CHOL, KIRP, and BRCA are the cancer types where H1-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.019	0.800	<.001	54	view →
KIRP	OS	Tertile	IV	0.099	0.463	.001	36	view →
BRCA	OS	Tertile	II,III,IV	0.864	0.924	.008	36	view →
LGG	DFS	Tertile	All	0.726	0.849	.001	36	view →
COAD	OS	Tertile	II,III,IV	0.515	0.805	.003	36	view →
MESO	DFS	Tertile	IV	0.749	0.245	.032	18	view →
ACC	DFS	Tertile	IV	0.012	0.310	.002	18	view →
CESC	OS	Tertile	II,III,IV	0.952	0.717	.029	12	view →
STAD	DFS	Tertile	All	0.464	0.596	.016	9	view →
THCA	DFS	Tertile	All	0.825	0.931	.026	9	view →
SKCM	OS	Tertile	III,IV	0.818	0.350	.041	3	view →
LIHC	DFS	Tertile	All	0.606	0.418	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

H1-8–CHOL (OS)

Open the CHOL breakdown →