H1-3

Across TCGA patient cohorts, H1-3 mutation is significantly associated with the RNA expression of many other genes, with 357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-3-associated genes across cancer lineages are RNU6-91P, SLC22A1, and VN2R19P. Each is linked with H1-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-3-to-partner and partner-to-H1-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-91P grouped by H1-3-low versus H1-3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-3→partner) and Y-score (partner→H1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-91P →	+0.350	+2.547	.007	.009	3	2
UCEC	SLC22A1 →	+0.333	+3.191	.005	.009	3	2
UCEC	VN2R19P →	+0.419	+3.002	<.001	.001	3	2
UCEC	PGAM5 →	+0.631	+3.584	.002	.003	3	2
COAD	RNU6-601P →	+0.581	+4.666	<.001	.005	3	2
COAD	ATP5MC1P1 →	+0.439	+4.037	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 357 associations by consensus.

RNU6-91P by H1-3 expression — UCEC

Explore this box plot interactively →