H1-3

Across TCGA pan-cancer cohorts, H1-3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated H1-3 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H1-3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H1-3 expression acts as an unfavorable survival marker, although some lineages such as DLBC and UVM show a favorable association.

ACC, LGG, and THCA are the cancer types where H1-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.365	0.770	<.001	88	view →
LGG	OS	Median	All	0.337	0.550	<.001	54	view →
THCA	OS	Quartile	III,IV	0.578	1.000	.001	49	view →
LIHC	OS	Median	All	0.599	0.800	<.001	34	view →
KIRP	DFS	Quartile	All	0.857	0.956	.004	32	view →
KIRC	DFS	Median	All	0.550	0.705	<.001	32	view →
DLBC	DFS	Quartile	All	1.000	0.221	.002	28	view →
KICH	DFS	Quartile	II,III,IV	0.591	1.000	.010	27	view →
UVM	OS	Tertile	II,III,IV	1.000	0.401	.005	21	view →
CESC	OS	Median	All	0.913	0.835	.003	20	view →
COAD	DFS	Quartile	III,IV	0.304	0.659	.017	13	view →
MESO	DFS	Tertile	IV	0.262	0.609	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

H1-3–ACC (OS)

Open the ACC breakdown →