H1-3

Across TCGA pan-cancer cohorts, H1-3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H1-3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H1-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H1-3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where H1-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.988	<.001	10	view →
LUAD	All	All	+1.242	<.001	8	view →
STAD	All	II,III,IV	+0.953	<.001	8	view →
KIRC	All	All	−0.371	<.001	7	view →
BRCA	All	III,IV	+1.326	<.001	6	view →
KICH	All	All	−1.029	<.001	6	view →
LUSC	Male	All	+0.992	<.001	6	view →
UCEC	All	All	+0.446	<.001	6	view →
BLCA	All	All	+1.315	.019	4	view →
CHOL	All	All	+0.613	.011	3	view →
READ	Male	All	+0.463	.032	2	view →
LIHC	All	II,III,IV	+0.142	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

H1-3–HNSC

Open the HNSC breakdown →