H1-3

Across TCGA patient cohorts, H1-3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-3-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK2, and Paxillin. Each is linked with H1-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-3-to-partner and partner-to-H1-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by H1-3-low versus H1-3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-3→partner) and Y-score (partner→H1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.702	+3.019	.023	.019	3	2
UCEC	JNK2 →	+0.233	+2.817	.025	.036	3	1
UCEC	Paxillin →	+0.350	+3.321	.009	.010	3	1
UCEC	BRD4 →	+0.355	+2.177	.011	.035	3	1
UCEC	p62 Lck ligand →	+0.356	+2.817	.036	.036	2	1
UCEC	Rab25 →	-0.594	-3.321	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by H1-3 expression — UCEC

Explore this box plot interactively →