H1-3

Across TCGA cell cohorts, H1-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,110 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H1-3-associated GO terms across cancer lineages are Regulation of stress granule assembly, Regulation of stem cell differentiation, and Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay. Each is linked with H1-3 in more than 4 cancer types. Because this analysis shows association rather than direction, both H1-3-to-partner and partner-to-H1-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stress granule assembly grouped by H1-3-low versus H1-3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-3→partner) and Y-score (partner→H1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of stress granule assembly →	+0.087	+0.270	<.001	.006	3	4
BLOOD_Leukemia	Regulation of stem cell differentiation →	+0.069	+0.745	<.001	<.001	3	4
BREAST	Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay →	+0.102	+0.598	.001	.002	2	5
LUNG_NSCLC_LUSC	Establishment of mitotic sister chromatid cohesion →	+0.111	+0.367	<.001	.004	3	4
SKIN	Vitamin transport →	-0.070	-0.224	.001	.003	3	4
KIDNEY	Positive regulation of signal transduction by p53 class mediator →	+0.085	+0.421	.008	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,110 associations by consensus.

Regulation of stress granule assembly by H1-3 expression — SKIN

Explore this box plot interactively →