H1-3

Across TCGA cell cohorts, H1-3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H1-3-associated genes across cancer lineages are SLC7A13, MAGEB5, and CCT8L2. Each is linked with H1-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-3-to-partner and partner-to-H1-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A13 grouped by H1-3-low versus H1-3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-3→partner) and Y-score (partner→H1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC7A13 →	+0.002	+3.925	<.001	.006	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
SKIN	CCT8L2 →	+0.086	+6.022	<.001	.001	3	1
SKIN	OR6C3 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GPR171 →	+0.014	+3.103	.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLC7A13 by H1-3 expression — BLOOD_Lymphoma

Explore this box plot interactively →