Q-omics provides the consensus-scored H1-12P profile across patient tissues and cancer cell-line models. H1-12P expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in OV. Among the 18 cancer types available for tumor–normal comparison, H1-12P is differentially expressed in 12, with the highest sampling consensus in LUAD. Additionally, H1-12P RNA expression shows 15,500 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight OV, LUAD, and ACC as cancer lineages where H1-12P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for H1-12P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes H1-12P survival associations across molecular data types. H1-12P RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible H1-12P RNA expression–survival associations across cancer types. High H1-12P expression shows unfavorable associations in ACC, KIRP, LUAD, READ and LGG, but favorable associations in OV. The OV Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify OV as the clearest survival context for H1-12P RNA expression.
This table summarizes H1-12P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for H1-12P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. H1-12P shows higher tumor expression in LUAD, LIHC, BLCA, LUSC, HNSC and BRCA. The LUAD box plot shows higher H1-12P RNA expression in tumor versus normal tissue (log2 FC = +1.447, t-test p < 0.001).
This table shows molecular features associated with H1-12P in patient tissues and cancer cell lines. In patient samples, H1-12P shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
