Across TCGA pan-cancer cohorts, H1-12P RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H1-12P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where H1-12P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H1-12P is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
LUAD, LIHC, and BLCA are the cancer types where H1-12P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-12P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.