H1-1

Across TCGA patient cohorts, H1-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,065 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible H1-1-associated proteins across cancer lineages are IRS1_S636, P3H1, and P3H3. Each is linked with H1-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-1-to-partner and partner-to-H1-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H1-1 versus IRS1_S636 in GBM, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-1→partner) and Y-score (partner→H1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IRS1_S636 →	+0.733	+2.381	<.001	.001	3	3
UCEC	P3H1 →	+0.419	+2.032	<.001	<.001	3	3
CCRCC	P3H3 →	+0.583	+0.745	.002	<.001	3	3
PDAC	PPP1R14C →	+0.954	+0.825	.001	.002	3	3
CCRCC	COL1A1 →	+0.603	+0.514	.001	.006	3	3
CCRCC	COL5A1 →	+0.686	+0.691	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,065 associations by consensus.

H1-1 vs IRS1_S636 — GBM

Explore this scatter interactively →