H1-1

Across TCGA pan-cancer cohorts, H1-1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated H1-1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H1-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H1-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

ACC, KICH, and LGG are the cancer types where H1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.033	0.641	<.001	63	view →
KICH	DFS	Median	II,III,IV	0.565	1.000	.004	48	view →
LGG	DFS	Tertile	All	0.566	0.758	<.001	33	view →
KIRC	DFS	Quartile	III,IV	0.247	0.534	<.001	33	view →
SKCM	DFS	Tertile	II,III,IV	0.564	0.758	<.001	26	view →
LUAD	DFS	Quartile	III,IV	0.789	0.599	.022	15	view →
UCS	OS	Tertile	IV	1.000	0.282	.022	12	view →
BRCA	OS	Quartile	IV	0.379	0.838	.004	12	view →
CESC	OS	Tertile	IV	0.668	0.220	.040	6	view →
TGCT	DFS	Quartile	All	0.891	0.634	.007	6	view →
ESCA	DFS	Median	IV	0.626	0.213	.026	6	view →
LIHC	DFS	Tertile	III,IV	0.223	0.481	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

H1-1–ACC (DFS)

Open the ACC breakdown →