H1-1

Across TCGA pan-cancer cohorts, H1-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of H1-1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where H1-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H1-1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where H1-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.173	<.001	5	view →
THCA	Male	All	−0.304	<.001	4	view →
HNSC	All	All	+0.048	.007	4	view →
KIRC	Male	All	−0.043	.003	4	view →
LUSC	All	All	+0.049	.011	2	view →
KIRP	All	All	−0.047	.008	2	view →
KICH	Male	All	−0.118	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

H1-1–LIHC

Open the LIHC breakdown →