H1-1

Across TCGA patient cohorts, H1-1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,895 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible H1-1-associated genes across cancer lineages are FCGR3B, CXCL5, and CXCR2. Each is linked with H1-1 in more than 6 cancer types. Because this analysis shows association rather than direction, both H1-1-to-partner and partner-to-H1-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H1-1 versus FCGR3B in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-1→partner) and Y-score (partner→H1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR3B →	+1.673	+1.108	<.001	<.001	3	7
UCEC	CXCL5 →	+2.516	+1.002	<.001	.003	3	6
LSCC	CXCR2 →	+1.030	+0.831	<.001	<.001	3	6
GBM	ADGRG3 →	+1.381	+0.736	<.001	<.001	3	6
GBM	CXCR1 →	+1.288	+0.862	<.001	<.001	3	5
GBM	CXCL8 →	+2.182	+0.604	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,895 associations by consensus.

H1-1 vs FCGR3B — GBM

Explore this scatter interactively →