H1-1

Across TCGA patient cohorts, H1-1 mutation is significantly associated with the RNA expression of many other genes, with 388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-1-associated genes across cancer lineages are MRM3, ATPAF2, and TSPY16P. Each is linked with H1-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-1-to-partner and partner-to-H1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRM3 grouped by H1-1-low versus H1-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-1→partner) and Y-score (partner→H1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRM3 →	+0.493	+3.467	.002	.002	3	2
UCEC	ATPAF2 →	+0.425	+3.223	.002	.009	3	2
ESCA	TSPY16P →	+0.216	+5.681	<.001	.003	3	2
BLCA	RNU6-841P →	+0.339	+5.018	<.001	.004	3	2
UCEC	IGHD6-13 →	+0.538	+2.622	.001	.007	3	2
UCEC	IGHV3OR16-13 →	+0.590	+2.311	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 388 associations by consensus.

MRM3 by H1-1 expression — UCEC

Explore this box plot interactively →