H1-1

Across TCGA patient cohorts, H1-1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-1-associated genes across cancer lineages are PRDX1, Rictor_pT1135, and VHL. Each is linked with H1-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-1-to-partner and partner-to-H1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by H1-1-low versus H1-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-1→partner) and Y-score (partner→H1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.284	+3.000	.006	.036	3	1
UCEC	Rictor_pT1135 →	-0.114	-3.459	.026	.005	3	1
UCEC	VHL →	-0.991	-3.321	.003	.010	3	1
UCEC	p62 Lck ligand →	+0.478	+3.459	.003	.005	2	1
UCEC	EGFR_pY1068 →	-0.251	-3.459	.046	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRDX1 by H1-1 expression — UCEC

Explore this box plot interactively →