H1-1

Across TCGA cell cohorts, H1-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 650 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible H1-1-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Regulation of nucleocytoplasmic transport, and Positive regulation of mRNA catabolic process. Each is linked with H1-1 in more than 4 cancer types. Because this analysis shows association rather than direction, both H1-1-to-partner and partner-to-H1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by H1-1-low versus H1-1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-1→partner) and Y-score (partner→H1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of protein localization to nucleus →	+0.058	+0.130	<.001	<.001	3	5
BREAST	Regulation of nucleocytoplasmic transport →	+0.076	+0.139	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mRNA catabolic process →	+0.042	+0.125	.005	.006	3	4
BREAST	Detection of abiotic stimulus →	-0.059	-0.109	.002	.007	2	5
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA catabolic process →	+0.039	+0.144	.001	.001	3	4
BREAST	Actin polymerization-dependent cell motility →	+0.127	+0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 650 associations by consensus.

Regulation of protein localization to nucleus by H1-1 expression — BREAST

Explore this box plot interactively →