Across TCGA patient cohorts, H1-0 mutation is significantly associated with the RNA expression of many other genes, with 1,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-0-associated genes across cancer lineages are RN7SL83P, DYNLT3P2, and RNU6-1213P. Each is linked with H1-0 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-0-to-partner and partner-to-H1-0 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-0→partner) and Y-score (partner→H1-0) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL83P →	+0.499	+4.392	<.001	.006	3	2
UCEC	DYNLT3P2 →	+0.495	+3.048	<.001	<.001	3	2
UCEC	RNU6-1213P →	+0.280	+4.176	<.001	<.001	3	2
BLCA	MIR301A →	+1.131	+5.251	<.001	.006	3	2
COAD	RNU6-661P →	+0.525	+4.251	<.001	.008	3	1
COAD	TRAJ57 →	+0.738	+3.957	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,470 associations by consensus.

Exploration

H1-0 survival (RNA) · tumor vs normal (RNA) · all H1-0 data types