Across TCGA patient cohorts, H1-0 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-0-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with H1-0 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-0-to-partner and partner-to-H1-0 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-0→partner) and Y-score (partner→H1-0) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.312	-3.169	.004	.018	3	1
UCEC	eIF4E →	+0.201	+3.183	.029	.009	3	1
UCEC	A-Raf_pS299 →	-0.142	-3.169	.006	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.251	-3.893	<.001	<.001	3	1
UCEC	JNK2 →	+0.289	+2.807	<.001	.003	3	1
UCEC	Ku80 →	+0.256	+2.128	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

H1-0 survival (RNA) · tumor vs normal (RNA) · all H1-0 data types