Across TCGA cell cohorts, H1-0 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,694 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H1-0-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Regulation of canonical Wnt signaling pathway, and Heterochromatin organization. Each is linked with H1-0 in more than 7 cancer types. Because this analysis shows association rather than direction, both H1-0-to-partner and partner-to-H1-0 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-0→partner) and Y-score (partner→H1-0) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of gene expression, epigenetic →	+0.052	+3.696	<.001	<.001	3	8
URINARY_TRACT	Regulation of canonical Wnt signaling pathway →	+0.049	+3.704	.001	.002	3	8
KIDNEY	Heterochromatin organization →	+0.038	+2.768	<.001	<.001	3	8
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.058	+2.266	.001	.002	3	7
LUNG_SCLC	Positive regulation of transcription regulatory region DNA binding →	+0.228	+1.611	<.001	.001	2	8
KIDNEY	Heterochromatin formation →	+0.041	+3.027	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,694 associations by consensus.

Exploration

H1-0 survival (RNA) · tumor vs normal (RNA) · all H1-0 data types