GXYLT1

Across TCGA patient cohorts, GXYLT1 mutation is significantly associated with the RNA expression of many other genes, with 1,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GXYLT1-associated genes across cancer lineages are RN7SKP43, OR10AA1P, and RNU6-1133P. Each is linked with GXYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GXYLT1-to-partner and partner-to-GXYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP43 grouped by GXYLT1-low versus GXYLT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GXYLT1→partner) and Y-score (partner→GXYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP43 →	+0.345	+6.734	<.001	<.001	3	2
LUSC	OR10AA1P →	+0.077	+5.273	.002	.006	3	2
CESC	RNU6-1133P →	+0.337	+5.669	<.001	.003	3	2
CESC	RN7SL690P →	+0.134	+5.010	<.001	.009	3	2
UCEC	RNA5SP436 →	+0.256	+2.545	<.001	.005	3	2
HNSC	RNA5SP70 →	+0.542	+7.954	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,228 associations by consensus.

RN7SKP43 by GXYLT1 expression — COAD

Explore this box plot interactively →