GUK1

Across TCGA patient cohorts, GUK1 mutation is significantly associated with the RNA expression of many other genes, with 993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUK1-associated genes across cancer lineages are UBE2V1P4, TRAJ46, and MIR548E. Each is linked with GUK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GUK1-to-partner and partner-to-GUK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P4 grouped by GUK1-low versus GUK1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUK1→partner) and Y-score (partner→GUK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2V1P4 →	+0.134	+5.103	<.001	.008	3	2
COAD	TRAJ46 →	+0.723	+4.516	<.001	.009	3	2
COAD	MIR548E →	+0.841	+4.893	<.001	.005	3	2
UCEC	TRAJ34 →	+0.510	+1.774	.001	.007	3	2
UCEC	RNA5SP420 →	+0.536	+1.967	<.001	.005	3	2
UCEC	RN7SL147P →	+0.132	+2.113	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 993 associations by consensus.

UBE2V1P4 by GUK1 expression — CESC

Explore this box plot interactively →