GUK1

Across TCGA pan-cancer cohorts, GUK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GUK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GUK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GUK1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where GUK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.003	<.001	12	view →
COAD	Female	II,III,IV	+1.266	<.001	11	view →
LIHC	Male	II,III,IV	+1.331	<.001	9	view →
HNSC	All	All	+0.412	<.001	8	view →
BRCA	Female	All	+0.450	<.001	6	view →
CHOL	Male	All	+1.724	<.001	5	view →
KICH	All	All	−0.600	<.001	5	view →
READ	All	All	+0.704	.040	2	view →
PAAD	All	All	+0.600	.033	2	view →
UCEC	All	All	+0.363	.005	2	view →
THCA	All	All	+0.188	.010	2	view →
KIRP	All	III,IV	+0.345	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GUK1–KIRC

Open the KIRC breakdown →