GUCY2D

Across TCGA patient cohorts, GUCY2D protein abundance is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GUCY2D-associated genes across cancer lineages are HSD3B7, DCUN1D4, and HEMGN. Each is linked with GUCY2D in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY2D-to-partner and partner-to-GUCY2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCY2D versus HSD3B7 in BRCA, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2D→partner) and Y-score (partner→GUCY2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSD3B7 →	+1.462	+0.687	.006	.002	3	2
BRCA	DCUN1D4 →	-1.235	-0.832	.003	.001	3	2
COAD	HEMGN →	+0.125	+0.387	.009	.005	3	1
COAD	RAB20 →	+0.452	+0.347	.007	.001	3	1
COAD	TMCO3 →	+0.627	+0.395	<.001	<.001	3	1
COAD	ATP5F1EP2 →	-1.454	-0.363	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

GUCY2D vs HSD3B7 — BRCA

Explore this scatter interactively →