GUCY2D

Across TCGA pan-cancer cohorts, GUCY2D RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GUCY2D data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GUCY2D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUCY2D expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

KIRC, UCEC, and BRCA are the cancer types where GUCY2D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.514	0.722	<.001	62	view →
UCEC	OS	Tertile	All	0.535	0.751	.001	60	view →
BRCA	OS	Quartile	All	0.958	0.893	<.001	48	view →
SCLC	OS	Quartile	III,IV	0.860	0.265	<.001	47	view →
ACC	DFS	Median	II,III,IV	0.163	0.788	<.001	44	view →
LGG	OS	Median	All	0.726	0.885	<.001	40	view →
ESCA	DFS	Tertile	All	0.889	0.345	.007	39	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	37	view →
UVM	OS	Tertile	All	0.386	1.000	.010	36	view →
SKCM	OS	Median	IV	0.836	0.372	<.001	33	view →
DLBC	DFS	Tertile	All	1.000	0.594	.003	31	view →
LIHC	DFS	Tertile	II,III,IV	0.299	0.541	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GUCY2D–KIRC (DFS)

Open the KIRC breakdown →