GUCY2C

Across TCGA patient cohorts, GUCY2C RNA expression is significantly associated with the protein abundance of many other proteins, with 7,197 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GUCY2C-associated proteins across cancer lineages are PTPN12_S673, PYGL, and RAB31. Each is linked with GUCY2C in more than 2 cancer types. Because this analysis shows association rather than direction, both GUCY2C-to-partner and partner-to-GUCY2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCY2C versus PTPN12_S673 in COAD, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2C→partner) and Y-score (partner→GUCY2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTPN12_S673 →	-0.289	-1.083	<.001	.001	3	3
HNSC	PYGL →	-0.530	-0.810	<.001	.001	3	3
PDAC	RAB31 →	-0.394	-0.898	.001	<.001	3	3
LSCC	ERRFI1_S251 →	-0.928	-0.550	<.001	<.001	3	3
LSCC	FAM117B_S449 →	+0.589	+0.649	<.001	<.001	3	3
LSCC	FMNL1 →	-0.340	-0.425	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,197 associations by consensus.

GUCY2C vs PTPN12_S673 — COAD

Explore this scatter interactively →