GUCY2C

Across TCGA pan-cancer cohorts, GUCY2C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GUCY2C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GUCY2C RNA is repressed in tumor relative to normal tissue. In most cancer types GUCY2C is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, LUAD, and THCA are the cancer types where GUCY2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCY2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.300	<.001	8	view →
LUAD	All	All	+0.536	<.001	7	view →
THCA	All	II,III,IV	−0.316	<.001	7	view →
BRCA	All	III,IV	−0.494	<.001	6	view →
KIRC	All	All	−0.222	<.001	5	view →
LIHC	All	All	+0.856	<.001	4	view →
STAD	All	All	+1.658	.008	2	view →
PRAD	All	All	−0.661	<.001	2	view →
COAD	Female	All	−0.595	.020	2	view →
KICH	All	All	+0.297	.009	2	view →
LUSC	All	All	+0.241	.002	2	view →
UCEC	All	All	−0.232	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GUCY2C–HNSC

Open the HNSC breakdown →