GUCY2C

Across TCGA pan-cancer cohorts, GUCY2C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GUCY2C data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GUCY2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GUCY2C expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

UVM, LGG, and HNSC are the cancer types where GUCY2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.329	0.708	<.001	100	view →
LGG	OS	Median	All	0.365	0.531	<.001	54	view →
HNSC	OS	Quartile	IV	0.809	0.569	<.001	48	view →
LIHC	OS	Median	All	0.400	0.608	<.001	48	view →
READ	OS	Median	II,III,IV	0.959	0.303	.001	41	view →
COAD	DFS	Quartile	III,IV	0.229	0.586	.001	29	view →
ESCA	OS	Median	All	0.617	1.000	.009	26	view →
UCS	OS	Tertile	IV	0.938	0.405	.024	24	view →
SKCM	OS	Median	III,IV	0.507	0.264	.003	23	view →
KIRC	DFS	Median	III,IV	0.550	0.394	.016	21	view →
THYM	DFS	Median	II,III,IV	0.936	0.761	.011	14	view →
BRCA	DFS	Tertile	IV	0.863	0.339	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GUCY2C–UVM (DFS)

Open the UVM breakdown →