GUCY2C

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GUCY2C protein abundance is significantly associated with the RNA expression of many other genes, with 2,157 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GUCY2C-associated genes across cancer lineages are ZC3H14, FAM86C2P, and ANTXR2. Each is linked with GUCY2C in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY2C-to-partner and partner-to-GUCY2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GUCY2C versus ZC3H14 in COAD, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2C→partner) and Y-score (partner→GUCY2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADZC3H14 →-0.507-0.675<.001<.00132
COADFAM86C2P →-0.386-0.554.001<.00132
COADANTXR2 →-0.758-0.695<.001<.00132
PDACRTKN2 →-0.990-0.987.005.00932
COADHMGN2 →-0.512-0.646.001<.00132
COADSDCCAG8 →-0.415-0.650<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,157 associations by consensus.

GUCY2C vs ZC3H14 — COAD

Per-sample scatter of GUCY2C vs ZC3H14 in COAD (Pearson r = -0.37).

Explore this scatter interactively →

Exploration