GUCY2C

Across TCGA patient cohorts, GUCY2C mutation is significantly associated with the RNA expression of many other genes, with 3,683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY2C-associated genes across cancer lineages are CHCHD1, BOLA3, and RNA5SP86. Each is linked with GUCY2C in more than 4 cancer types. Because this analysis shows association rather than direction, both GUCY2C-to-partner and partner-to-GUCY2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD1 grouped by GUCY2C-low versus GUCY2C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2C→partner) and Y-score (partner→GUCY2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CHCHD1 →	+0.202	+1.403	.003	.006	3	5
UCEC	BOLA3 →	+0.294	+1.999	.004	.002	3	4
BRCA	RNA5SP86 →	+0.107	+4.133	<.001	.007	3	3
UCEC	MYO19 →	+0.362	+1.736	.001	<.001	3	3
UCEC	ADK →	+0.360	+2.108	.007	.002	3	3
UCEC	SUPV3L1 →	+0.312	+1.747	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,683 associations by consensus.

CHCHD1 by GUCY2C expression — SKCM

Explore this box plot interactively →