GUCY2C

Across TCGA cell cohorts, GUCY2C mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GUCY2C-associated genes across cancer lineages are OR10Q1, GNG8, and XCR1. Each is linked with GUCY2C in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCY2C-to-partner and partner-to-GUCY2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q1 grouped by GUCY2C-low versus GUCY2C-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY2C→partner) and Y-score (partner→GUCY2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10Q1 →	+0.653	+5.643	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	GNG8 →	+0.343	+3.510	<.001	.007	3	2
BLOOD_Leukemia	XCR1 →	+0.027	+4.415	.005	.001	3	2
BLOOD_Leukemia	NANOS2 →	+0.031	+3.455	<.001	.002	3	2
BLOOD_Leukemia	ADRA2B →	+0.147	+3.514	<.001	.008	3	2
BLOOD_Leukemia	F11 →	+0.093	+3.177	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

OR10Q1 by GUCY2C expression — LUNG_SCLC

Explore this box plot interactively →