GUCY1B1

Across TCGA patient cohorts, GUCY1B1 mutation is significantly associated with the RNA expression of many other genes, with 2,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCY1B1-associated genes across cancer lineages are C1QBP, MRS2, and RNU2-65P. Each is linked with GUCY1B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GUCY1B1-to-partner and partner-to-GUCY1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by GUCY1B1-low versus GUCY1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCY1B1→partner) and Y-score (partner→GUCY1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QBP →	+0.507	+2.823	.005	.001	3	3
UCEC	MRS2 →	+0.416	+3.459	.004	.005	3	3
LUAD	RNU2-65P →	+0.313	+4.013	.001	.001	3	3
UCEC	SEC13 →	+0.344	+2.156	.005	.009	3	3
UCEC	THOP1 →	+0.501	+2.098	.001	.003	3	3
UCEC	COASY →	+0.470	+2.108	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,401 associations by consensus.

C1QBP by GUCY1B1 expression — UCEC

Explore this box plot interactively →