GUCY1B1

Across TCGA pan-cancer cohorts, GUCY1B1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GUCY1B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GUCY1B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GUCY1B1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where GUCY1B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCY1B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.393	<.001	12	view →
KICH	All	III,IV	−2.445	<.001	11	view →
KIRC	Female	All	+1.471	<.001	11	view →
KIRP	Male	II,III,IV	+1.248	<.001	8	view →
UCEC	All	All	−1.857	<.001	6	view →
LUAD	All	All	−0.335	.004	6	view →
THCA	All	All	+0.645	<.001	5	view →
CHOL	Female	All	+3.206	<.001	3	view →
LUSC	All	All	−0.532	.001	3	view →
READ	Female	All	−1.730	.034	1	view →
LIHC	Female	All	+0.550	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GUCY1B1–HNSC

Open the HNSC breakdown →